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Thymine Modified Amphiphilic Biodegradable Copolymers for Photo‐ C ross‐ L inked Micelles as Stable Drug Carriers
Author(s) -
Kuang Huihui,
He Hongyan,
Hou Jie,
Xie Zhigang,
Jing Xiabin,
Huang Yubin
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300254
Subject(s) - micelle , amphiphile , copolymer , dynamic light scattering , chemistry , thymine , drug delivery , drug carrier , hela , polymer chemistry , nanoparticle , materials science , combinatorial chemistry , organic chemistry , aqueous solution , nanotechnology , in vitro , biochemistry , dna , polymer
A photo‐cross‐linked micelle is synthesized via photodimerization of thymine moieties fabricated from amphiphilic block copolymers (mPEG‐ b ‐P(LA‐ co ‐MPT). The crosslinking behavior is monitored by UV‐Vis spectra and 1 H NMR. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) showed that cross‐linked micelles had smaller sizes than their uncross‐linked precursors. In vitro studies reveal that cross‐linking of the micelle cores results in a slow drug release and faster cellular uptake in comparison with uncross‐linked ones in MCF‐7 and Hela cells. Moreover, the paclitaxel (PTX)‐loaded core‐cross‐linked micelles exhibit similar anticancer efficacy as free PTX. This work provides a convenient tool for designing a more stable structure in the blood circulation to realize a controlled drug delivery.