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In Vitro Investigations of Smart Drug Delivery Systems Based on Redox‐ S ensitive Cross‐ L inked Micelles
Author(s) -
Cajot Sébastien,
Schol Daureen,
Danhier Fabienne,
Préat Véronique,
Gillet De Pauw MarieClaire,
Jérôme Christine
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300250
Subject(s) - micelle , nanocarriers , chemistry , linker , bifunctional , redox , copolymer , drug delivery , click chemistry , internalization , ethylene oxide , combinatorial chemistry , azide , polymer chemistry , organic chemistry , polymer , aqueous solution , biochemistry , cell , computer science , catalysis , operating system
Redox‐sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ‐caprolactone) and poly(α‐azide‐ϵ‐caprolactone). Stability of these micelles is insured in diluted media by cross‐linking their core via the addition of a bifunctional cross‐linker, while redox sensitivity is provided to these micelles by inserting a disulfide bridge in the cross‐linker. The potential of these responsive micelles to be used as nanocarriers is studied in terms of cytotoxicity and cellular internalization. The release profiles are also investigated by varying the environment reductive strength.