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Engineered Spider Silk Protein‐ B ased Composites for Drug Delivery
Author(s) -
Hardy John G.,
LealEgaña Aldo,
Scheibel Thomas R.
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300233
Subject(s) - spider silk , silk , biocompatibility , polycaprolactone , drug delivery , polyester , biocompatible material , polyurethane , biodegradation , materials science , chemistry , polymer science , composite material , biomedical engineering , nanotechnology , polymer , organic chemistry , medicine
Silk protein‐based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk‐based composites have potential as drug eluting biocompatible coatings or implantable devices.