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Enhanced Adhesion of Preosteoblasts inside 3 D PCL Scaffolds by Polydopamine Coating and Mineralization
Author(s) -
Jo Sunae,
Kang Sung Min,
Park Su A.,
Kim Wan Doo,
Kwak Juhyoun,
Lee Haeshin
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300203
Subject(s) - chemistry , wetting , adhesion , scaffold , coating , cell adhesion , infiltration (hvac) , tissue engineering , surface modification , biophysics , nanotechnology , materials science , biomedical engineering , composite material , organic chemistry , medicine , biology
In tissue engineering, fabrication of 3D scaffolds with well‐defined, inter‐connected pores followed by culture of mammalian cells is a typical approach. In practice, however, hydrophobicity of scaffold surfaces is not suitable for cells to be adhered because of poor wettability. Especially, infiltration followed by adhesion of cells inside hydrophobic scaffolds remains as a challenge. Thus, hydrophilic conversions of the surfaces regardless of surface location are critical for success. Herein, a method to enhance infiltration and adhesion of preosteoblasts inside hydrophobic poly(ϵ‐caprolactone) (PCL) scaffolds by a bio‐inspired, hydroxyapatite formation is demonstrated. The approach can be a general method for controlling hydrophilicity of inner surfaces of scaffolds.