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Preparation of Biodegradable Peptide Nanospheres with Hetero PEG Brush Surfaces
Author(s) -
Matsumoto Masahiro,
Matsusaki Michiya,
Akashi Mitsuru
Publication year - 2014
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300201
Subject(s) - brush , peg ratio , peptide , chemistry , brush border , polymer chemistry , chemical engineering , nanotechnology , materials science , vesicle , biochemistry , membrane , composite material , engineering , finance , economics
Abstract Controlled hetero poly(ethylene glycol) (PEG) brushes composed of higher and lower molecular weight PEG chains are for the first time prepared onto biodegradable peptide nanospheres. Hence, the PEG chains are easily detached and re‐attached based on the thiol‐disulfide chemistry of the interfacial disulfide bonds of PEG‐SS‐peptide nanospheres. The density of the 1 st PEG with a molecular weight of 2000 (M ¯ w = 2k) is controlled by altering the reduction conditions. Subsequently, 2 nd PEG chains with a higherM ¯ w(from 5000 to 20 000) are constructed by oxidative reactions. Hetero PEG 2k 60%/PEG 5k 40% demonstrates about 2.5‐fold greater protein resistance than homo PEG 2k 100% or PEG 5k 40%, and exceptional dispersion stability in serum for over three weeks. Hetero PEG brush peptide nanospheres will be useful as bioinert drug carriers for biomedical applications.