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Redox‐ S ensitive Shell‐ C rosslinked Polypeptide ‐block‐ P olysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery
Author(s) -
Zhang Aiping,
Zhang Zhe,
Shi Fenghua,
Xiao Chunsheng,
Ding Jianxun,
Zhuang Xiuli,
He Chaoliang,
Chen Li,
Chen Xuesi
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300175
Subject(s) - chemistry , biocompatibility , drug delivery , intracellular , micelle , amphiphile , hela , glutathione , biophysics , drug carrier , coacervate , mtt assay , combinatorial chemistry , nuclear chemistry , biochemistry , copolymer , organic chemistry , in vitro , aqueous solution , biology , enzyme , polymer
Redox‐responsive SCMs based on amphiphilic PBLG ‐b‐ dextran with good biocompatibility are synthesized and used for efficient intracellular drug delivery. The molecular structures and SCMs characteristics are characterized by 1 H NMR, FT‐IR, TEM, and DLS. The hydrodynamic radius of SCMs increases gradually in PBS due to the cleavage of disulfide bond in micellar shell caused by the presence of GSH. The encapsulation efficiency and release kinetics of DOX are investigated. The fastest DOX release is observed under intracellular‐mimicking reductive environments. An MTT assay demonstrates that DOX‐loaded SCMs show higher cellular proliferation inhibition against GSH‐OEt pretreated HeLa and HepG2 than that of the non‐pretreated and BSO‐pretreated ones.