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Improved MIN 6 β‐ C ell Function on Self‐ A ssembled Peptide Amphiphile Nanomatrix Inscribed with Extracellular Matrix‐ D erived Cell Adhesive Ligands
Author(s) -
Lim DongJin,
Antipenko Sergey V.,
Vines Jeremy B.,
Andukuri Adinarayana,
Hwang Patrick T. J.,
Hadley Nathan T.,
Rahman Shibli M.,
Corbett John A.,
Jun HoWook
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300155
Subject(s) - chemistry , peptide , biochemistry
Understanding the role of the pancreatic extracellular matrix (ECM) in supporting islet survival and function drives the pursuit to create biomaterials that imitate and restore the pancreatic ECM microenvironment. To create an ECM mimic holding bioinductive cues for β‐cells, self‐assembled peptide amphiphiles (PAs) inscribed with four selected ECM‐derived cell adhesive ligands are synthesized. After 7 days, compared to control groups cultured on biologically inert substrates, MIN6 β‐cells cultured on PAs functionalized with YIGSR and RGDS cell adhesive ligands exhibit elevated insulin secretion in responses to glucose and also form β‐cell clusters. These findings suggest that the self‐assembled PA nanomatrix may be utilized to improve pancreatic islet transplantation for treating type 1 diabetes.