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Quantitative Contrasts in the Photopolymerization of Acrylamide and Methacrylamide‐ F unctionalized Gelatin Hydrogel Building Blocks
Author(s) -
Billiet Thomas,
Gasse Bjorn Van,
Gevaert Elien,
Cornelissen Maria,
Martins José C.,
Dubruel Peter
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300143
Subject(s) - methacrylamide , gelatin , acrylamide , self healing hydrogels , swelling , photopolymer , chemistry , polymer chemistry , magic angle spinning , polymerization , polymer science , photoinitiator , chemical engineering , polymer , organic chemistry , nuclear magnetic resonance spectroscopy , copolymer , monomer , engineering
The synthesis and evaluation of gelatin acrylamide as an alternative to the well‐established gelatin methacrylamide are reported. High‐resolution magic angle spinning NMR is used for the quantitative determination of the chemical cross‐linking density. The gelatin acrylamide precursors reveal enhanced cross‐linking in terms of reactivity and double bond conversion, resulting in stronger networks. Remarkably, even at very low double bond conversions, ≈5%, gel fractions of ≈40% are obtained. The cross‐linked networks are also reviewed in the framework of the rubber elasticity and thermodynamic swelling theories to estimate important nanostructural properties. Preliminary cell tests revealed that highly viable (>90%) cell‐laden constructs are obtained.