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Responsive Materials for Self‐ R egulated Insulin Delivery
Author(s) -
Wu Weitai,
Zhou Shuiqin
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300120
Subject(s) - insulin delivery , boronic acid , insulin , delivery system , chemistry , perspective (graphical) , nanotechnology , computer science , diabetes mellitus , biochemistry , engineering , microbiology and biotechnology , materials science , combinatorial chemistry , medicine , biology , biomedical engineering , type 1 diabetes , endocrinology , artificial intelligence
With diabetes mellitus becoming an important public health concern, insulin‐delivery systems are attracting increasing interest from both scientific and technological researchers. This feature article covers the present state‐of‐the‐art glucose‐responsive insulin‐delivery system (denoted as GRIDS), based on responsive polymer materials, a promising system for self‐regulated insulin delivery. Three types of GRIDS are discussed, based on different fundamental mechanisms of glucose‐recognition, with: a) glucose enzyme, b) glucose binding protein, and c) synthetic boronic acid as the glucose‐sensitive component. At the end, a personal perspective on the major issues yet to be worked out in future research is provided.