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Calcium‐ M ediated Secondary Cross‐ L inking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels
Author(s) -
Nejadnik M. Reza,
Yang Xia,
Mimura Tokio,
Birgani Zeinab Tahmasebi,
Habibovic Pamela,
Itatani Kiyoshi,
Jansen John A.,
Hilborn Jons,
Ossipov Dmitri,
Mikos Antonios G.,
Leeuwenburgh Sander C. G.
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300117
Subject(s) - self healing hydrogels , ethylene glycol , chemistry , calcium , peg ratio , polymer , polymer chemistry , divalent , surface modification , chemical engineering , organic chemistry , finance , economics , engineering
This study demonstrates, for the first time, that synthetic PEG‐based hydrogels can be cross‐linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg 2+ and Ca 2+ . More specifically, it is shown that BP‐functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross‐linkers.