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Incorporation of Poly[( R )‐3‐hydroxybutyrate] into Cationic Copolymers Based on Poly(2‐(dimethylamino)ethyl methacrylate) to Improve Gene Delivery
Author(s) -
Loh Xian Jun,
Ong Shi Jie,
Tung Yin Ting,
Choo Hoi Teng
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201300050
Subject(s) - copolymer , methacrylate , cationic polymerization , amphiphile , gene delivery , polymer chemistry , transfection , chemistry , polymer , organic chemistry , gene , biochemistry
The synthesis and gene transfection efficiency of a series of novel amphiphilic triblock copolymers with two hydrophilic poly(2‐(dimethylamino)ethyl methacrylate) (DMAEMA) blocks flanking a central hydrophobic poly[(R)‐3‐hydroxybutyrate] (PHB) block is reported. These copolymers have significantly lower toxicity compared to the polyethyleneimine (PEI) and PDMAEMA homopolymer. Unexpectedly, the incorporation of PHB significantly improves the gene transfection efficiency as compared to PEI or PDMAEMA homopolymers.