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Stable Acid‐ R esponsive Electrospun Biodegradable Fibers as Drug Carriers and Cell Scaffolds
Author(s) -
Zhao Jingwen,
Liu Shen,
Li Bin,
Yang Huilin,
Fan Cunyi,
Cui Wenguo
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200452
Subject(s) - scaffold , tissue engineering , electrospinning , polylactic acid , chemistry , emulsion , chemical engineering , polymer chemistry , biomedical engineering , polymer , organic chemistry , medicine , engineering
Acid‐responsive electrospun fibers are fabricated by introducing sodium bicarbonate into PLLA fibers using an emulsion method. This novel electrospun fibrous scaffold exhibits a rapid acid‐responsive controlled drug release (early stage) and stable three‐dimensional (3D) structure as a tissue engineering scaffold (late stage) for cell growth.