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A Novel 3 D Integrated Platform for the High‐ R esolution Study of Cell Migration Plasticity
Author(s) -
Schneider Julian,
Bachmann Tobias,
Franco Davide,
Richner Patrizia,
Galliker Patrick,
Tiwari Manish K.,
Ferrari Aldo,
Poulikakos Dimos
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200416
Subject(s) - microporous material , cell migration , microscopy , plasticity , biophysics , nanotechnology , chemistry , optical microscope , materials science , cell , optics , biology , composite material , biochemistry , physics , scanning electron microscope
Understanding the mechanisms of interstitial cancer migration is of great scientific and medical interest. Creating 3D platforms, conducive to optical microscopy and mimicking the physical parameters (in plane and out of plane) involved in interstitial migration, is a major step forward in this direction. Here, a novel approach is used to directly print free‐form, 3D micropores on basal scaffolds containing microgratings optimized for contact guidance. The platforms so formed are validated by monitoring cancer cell migration and micropore penetration with high‐resolution optical microscopy. The shapes, sizes and deformability of the micropores are controllable, paving the way to decipher their role in interstitial migration.