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Fluorescent Polymeric Micelles with Aggregation‐Induced Emission Properties for Monitoring the Encapsulation of Doxorubicin
Author(s) -
Chen JenIng,
Wu WenChung
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200396
Subject(s) - micelle , amphiphile , chemistry , fluorescence , ethylene glycol , copolymer , förster resonance energy transfer , methacrylate , nile red , doxorubicin , peg ratio , biophysics , chemical engineering , polymer chemistry , organic chemistry , polymer , aqueous solution , medicine , physics , surgery , chemotherapy , quantum mechanics , engineering , biology , finance , economics
A new type of fluorescent polymeric micelles is developed by self‐assembly from a series of amphiphilic block copolymers, poly(ethylene glycol)‐ b ‐poly[styrene‐ co ‐(2‐(1,2,3,4,5‐pentaphenyl‐1H‐silol‐1‐yloxy)ethyl methacrylate)] [PEG‐ b ‐P(S‐ co ‐PPSEMA)]. Their capability of loading doxorubicin (DOX) is investigated by monitoring the loading content, encapsulation efficiency, and photophysical properties of micelles. Förster resonance energy transfer from PPSEMA to DOX is observed in DOX‐loaded micelles, which can serve as an indication of successful encapsulation of DOX in these micelles. The application of this new type of fluorescent polymeric micelles as a fluorescent probe and an anticancer drug carrier simultaneously is explored by studying the intracellular uptake of DOX‐loaded micelles.