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Scaffold Effects on Osteogenic Differentiation of Equine Mesenchymal Stem Cells: An In Vitro Comparative Study
Author(s) -
NinoFong Rodolfo,
McDuffee Laurie A.,
Esparza Gonzalez Blanca P.,
Kumar M. Ramesh,
Merschrod S. Erika F.,
Poduska Kristin M.
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200355
Subject(s) - mesenchymal stem cell , scaffold , in vitro , chemistry , stem cell , microbiology and biotechnology , biomedical engineering , biology , biochemistry , medicine
The in vitro viability, osteogenic differentiation, and mineralization of four different equine mesenchymal stem cells (MSCs) from bone marrow, periosteum, muscle, and adipose tissue are compared, when they are cultured with different collagen‐based scaffolds or with fibrin glue. The results indicate that bone marrow cells are the best source of MSCs for osteogenic differentiation, and that an electrochemically aggregated collagen gives the highest cell viability and best osteogenic differentiation among the four kinds of scaffolds studied.