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Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells
Author(s) -
Mauro Nicolò,
Manfredi Amedea,
Ranucci Elisabetta,
Procacci Patrizia,
Laus Michele,
Antonioli Diego,
Mantovani Cristina,
Magnaghi Valerio,
Ferruti Paolo
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200354
Subject(s) - piperazine , self healing hydrogels , biocompatibility , regeneration (biology) , tissue engineering , chemistry , in vivo , biophysics , adhesion , poly(amidoamine) , materials science , amidoamine , polymer chemistry , biomedical engineering , organic chemistry , microbiology and biotechnology , dendrimer , biology , medicine
This paper reports on the synthesis and physico‐chemical, mechanical, and biological characterization of two sets of poly(amidoamine) (PAA) hydrogels with potential as scaffolds for in vivo peripheral nerve regeneration. They are obtained by polyaddition of piperazine with N , N ′‐methylenebis(acrylamide) or 1,4‐bis(acryloyl)piperazine with 1,2‐diaminoethane as cross‐linking agent and exhibit a combination of relevant properties, such as mechanical strength, biocompatibility, biodegradability, ability to induce adhesion and proliferation of Schwann cells (SCs) preserving their viability. Moreover, the most promising hydrogels, that is those deriving from 1,4‐bis(acryloyl)piperazine, allow the in vitro growth of the sensitive neurons of the dorsal root ganglia, thus getting around a critical point in the design of conduits for nerve regeneration.