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Human Mesenchymal Stem‐Cell Behaviour On Direct Laser Micropatterned Electrospun Scaffolds with Hierarchical Structures
Author(s) -
Li Huaqiong,
Wong Yee Shan,
Wen Feng,
Ng Kee Woei,
Ng Gary Ka Lai,
Venkatraman Subbu S.,
Boey Freddy Yin Chiang,
Tan Lay Poh
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200318
Subject(s) - mesenchymal stem cell , scaffold , extracellular matrix , electrospinning , microbiology and biotechnology , stem cell , tissue engineering , chemistry , nanotechnology , materials science , biomedical engineering , biology , medicine , polymer , organic chemistry
Direct laser machining and electrospinning are utilized to obtain a bi‐layered hybrid scaffold with hierarchical topographical features to mimic extracellular matrix‐like microenvironment of cells. Adult bone marrow derived human mesenchymal stem cells (hMSCs) are cultured in vitro in these hybrid scaffolds, and cell orientation, proliferation, viability, and differentiation are evaluated. The results show that this novel hybrid scaffold not only supports cell growth like traditional scaffolds, but also elicits positive responses from the cells, like lineage commitment and alignment, which are essential features of future scaffolds.