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Biocompatible Fibrous Networks of Cellulose Nanofibres and Collagen Crosslinked Using Genipin: Potential as Artificial Ligament/Tendons
Author(s) -
Mathew Aji P.,
Oksman Kristiina,
Pierron Dorothée,
Harmand MarieFrançoise
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200317
Subject(s) - genipin , biocompatible material , cellulose , ligament , biocompatibility , chemistry , biomedical engineering , materials science , polymer science , chitosan , anatomy , organic chemistry , medicine
Bio‐based fibrous nanocomposites of cellulose nanofibres and non‐crosslinked/crosslinked collagen were prepared by in situ pH‐induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio‐based crosslinker that introduces flexible crosslinks. Microscopy studies of the prepared materials showed nanostructured fibrous collagen and cellulose dispersed in collagen matrix. Mechanical performance of the sterilized nanocomposites was close to that of natural ligament and tendon, in simulated body conditions. Cytocompatibility studies indicated that these nanocomposites allowed human ligament cell and human endothelial cell adhesion, growth, and differentiation; which is eminently favourable to ligament tissue engineering.