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Bifunctional Nanoparticles Constructed Using One‐Pot Encapsulation of a Fluorescent Polymer and Magnetic (Fe 3 O 4 ) Nanoparticles in a Silica Shell
Author(s) -
Lee ChangSoo,
Chang Hee Hyun,
Bae PanKee,
Jung Juyeon,
Chung Bong Hyun
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200308
Subject(s) - nanoparticle , bifunctional , superparamagnetism , nanotechnology , polymer , magnetic nanoparticles , fluorescence , silicon dioxide , iron oxide nanoparticles , materials science , chemistry , surface modification , nanostructure , chemical engineering , organic chemistry , magnetization , physics , quantum mechanics , magnetic field , engineering , catalysis , metallurgy
Integration of biocompatible silica with a fluorescent polymer (PDDF) and superparamagnetic iron oxide nanoparticles (Fe 3 O 4 ) to form uniform core–shell nanostructures has the great potential to form particles for use in multimodal bioimaging applications. Core–shell nanoparticles (PDDF/Fe 3 O 4 @SiO 2 ) exhibit fluorescent and magnetic properties that are favorable for their use in magnetic separation and guiding applications, as well as optical and magnetic resonance (MR) imaging capabilities. With the biological analysis in an in vitro intracellular permeation and cytotoxicity test, chemical conjugation of the surface using folic acid (FA) molecules can provide the nanoparticles with cell‐targeting properties, localizing the nanoparticles to folate receptors (FRs) on target KB cells that over‐express the FRs.