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One‐Step Preparation and pH‐Tunable Self‐Aggregation of Amphoteric Aliphatic Polycarbonates Bearing Plenty of Amine and Carboxyl Groups
Author(s) -
Wang HuaFen,
Jia HuiZhen,
Zhu JingYi,
Chu YanFeng,
Feng Jun,
Zhang XianZheng,
Zhuo RenXi
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200295
Subject(s) - copolymer , monomer , amine gas treating , chemistry , polymer chemistry , polymerization , polycarbonate , nanoparticle , polymer , organic chemistry , chemical engineering , engineering
This paper reports a novel amphoteric aliphatic polycarbonate bearing both amine and carboxyl groups. In the absence of protection‐deprotection chemistry, the multi‐functionalized copolymer is synthesized by one‐step enzymatic copolymerization. The influences of the reaction conditions including monomer feed ratio and polymerization time are explored. The simultaneous incorporation of amine and carboxyl functionalities provides the copolymer with a pH‐tunable self‐aggregation feature, leading to various aggregation states including precipitated agglomerate, well‐dispersed positively or negatively charged nanoparticles in a controlled manner. The copolymer displays minimal cytotoxicity to 293T and HeLa cells.