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Poly( N ‐vinylpyrrolidone)‐Modified Surfaces for Biomedical Applications
Author(s) -
Liu Xiaoli,
Xu Yajun,
Wu Zhaoqiang,
Chen Hong
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200269
Subject(s) - biocompatibility , ethylene glycol , surface modification , protein adsorption , biofouling , polymer , peg ratio , chemical engineering , chemistry , adsorption , n vinylpyrrolidone , chemical modification , chemical stability , nanotechnology , materials science , polymer chemistry , copolymer , organic chemistry , membrane , biochemistry , finance , engineering , economics
Poly( N ‐vinylpyrrolidone) (PVP), an important water soluble synthetic polymer, has many desirable properties including low toxicity, chemical stability, and good biocompatibility. Since PVP is hemocompatible and physiologically inactive, it has been used as a blood plasma substitute. Surface modification with PVP has been investigated extensively over the past few years as a means of preventing nonspecific protein adsorption. PVP may therefore be seen as a promising antifouling surface modifier comparable to poly(ethylene glycol) (PEG). In this review, various approaches for the design and preparation of PVP‐modified surfaces are summarized and potential biomedical applications of these PVP‐modified materials are indicated. Finally, some perspectives on future research on PVP for surface modification are discussed.