In vitro 3D Full‐Thickness Skin‐Equivalent Tissue Model Using Silk and Collagen Biomaterials | Zendy

Bellas Evangelia | Zendy; Seiberg Miri | Zendy; Garlick Jonathan | Zendy; Kaplan David L. | Zendy

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In vitro 3D Full‐Thickness Skin‐Equivalent Tissue Model Using Silk and Collagen Biomaterials

Author(s) -

Bellas Evangelia,

Seiberg Miri,

Garlick Jonathan,

Kaplan David L.

Publication year - 2012

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.201200262

Subject(s) - dermis , skin equivalent , epidermis (zoology) , silk , in vitro , keratin , adipose tissue , chemistry , biomedical engineering , anatomy , microbiology and biotechnology , materials science , pathology , keratinocyte , biology , biochemistry , medicine , composite material

Current approaches to skin equivalents often only include the epidermis and dermis. Here, a full‐thickness skin equivalent is described including epidermis, dermis, and hypodermis, that could serve as an in vitro model for studying skin biology or as a platform for consumer product testing. The construct is easy to handle and is maintained for >14 d while expressing physiological morphologies of the epidermis and dermis, seen by keratin 10, collagens I and IV expression. The skin equivalent produces glycerol and leptin, markers of adipose metabolism. This work serves as a foundation for understanding a few necessary factors needed to develop a stable, functional model of full‐thickness skin.

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