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Bio‐based Biodegradable and Biocompatible Hyperbranched Polyurethane: A Scaffold for Tissue Engineering
Author(s) -
Das Beauty,
Chattopadhyay Pronobesh,
Mandal Manabendra,
Voit Brigitte,
Karak Niranjan
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200244
Subject(s) - biocompatibility , tissue engineering , scaffold , polyurethane , pentaerythritol , biodegradation , chemistry , biomaterial , mtt assay , biocompatible material , ethylene glycol , materials science , polymer chemistry , biomedical engineering , in vitro , organic chemistry , biochemistry , medicine , fire retardant
Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (1–5 wt%) as the B 4 reactant with and without the monoglyceride of sunflower oil. The biodegradation, physico‐mechanical, and thermal properties are found to be tailored by varying the percentage weight of the branching unit. An MTT/hemolytic assay and subcutaneous implantation in Wistar rats followed by cytokine/ALP assay and histopathology studies confirm a better biocompatibility of HBPU with MG than without MG. HBPU supports the proliferation of dermatocytes with no toxic effect in major organs, in addition the in vitro degraded products are non‐toxic. Cell adherence and proliferation endorse the bio‐based HBPU as a prospective scaffold material in the niche of tissue engineering.