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Biocompatible Multishell Architecture for Iron Oxide Nanoparticles
Author(s) -
Wotschadlo Jana,
Liebert Tim,
Clement Joachim H.,
Anspach Nils,
Höppener Stephanie,
Rudolph Tobias,
Müller Robert,
Schacher Felix H.,
Schubert Ulrich S.,
Heinze Thomas
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200243
Subject(s) - nanoparticle , zeta potential , iron oxide nanoparticles , iron oxide , polyelectrolyte , nanotechnology , chemical engineering , magnetic nanoparticles , coating , particle (ecology) , materials science , scanning electron microscope , chemistry , composite material , polymer , metallurgy , oceanography , geology , engineering
Abstract The coating of super‐paramagnetic iron oxide nanoparticles (SPIONs) with multiple shells is demonstrated by building a layer assembled from carboxymethyldextran and poly(diallydimethylammonium chloride). Three shells are produced stepwise around aggregates of SPIONs by the formation of a polyelectrolyte complex. A growing particle size from 96 to 327 nm and a zeta potential in the range of +39 to −51 mV are measured. Microscopic techniques such as TEM, SEM, and AFM exemplify the core‐shell structures. Magnetic force microscopy and vibrating sample magnetometer measurements confirm the architecture of the multishell particles. Cell culture experiments show that even nanoparticles with three shells are still taken up by cells.