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Low Band Gap Donor‐Acceptor Conjugated Polymer Nanoparticles and their NIR‐mediated Thermal Ablation of Cancer Cells
Author(s) -
MacNeill Christopher M.,
Coffin Robert C.,
Carroll David L.,
LeviPolyachenko Nicole H.
Publication year - 2013
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200241
Subject(s) - photothermal therapy , conjugated system , polymer , nanoparticle , polymerization , chemistry , photochemistry , aqueous solution , band gap , thermal stability , viability assay , materials science , nanotechnology , nuclear chemistry , optoelectronics , cell , organic chemistry , biochemistry
Low band gap D‐A conjugated PNs consisting of 2‐ethylhexyl cyclopentadithiophene co‐polymerized with 2,1,3‐benzothiadiazole (for nano‐PCPDTBT) or 2,1,3‐benzoselenadiazole (for nano‐PCPDTBSe) have been developed. The PNs are stable in aqueous media and showed no significant toxicity up to 1 mg · mL −1 . Upon exposure to 808 nm light, the PNs generated temperatures above 50 °C. Photothermal ablation studies of the PNs with RKO and HCT116 colorectal cancer cells were performed. At concentrations above 100 µg · mL −1 for nano‐PCPDTBSe, cell viability was less than 20%, while at concentrations above 62 µg · mL −1 for nano‐PCPDTBT, cell viability was less than 10%. The results of this work demonstrate that low band gap D‐A conjugated polymers 1) can be formed into nanoparticles that are stable in aqueous media; 2) are non‐toxic until stimulated by IR light and 3) have a high photothermal efficiency.