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Permanent Polymer Coating for in vivo MRI Visualization of Tissue Reinforcement Prostheses
Author(s) -
Guillaume Olivier,
Blanquer Sébastien,
Letouzey Vincent,
Cornille Arnaud,
Huberlant Stephanie,
Lemaire Laurent,
Franconi Florence,
de Tayrac Renaud,
Coudane Jean,
Garric Xavier
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200208
Subject(s) - shrinkage , biomedical engineering , in vivo , polymer , coating , polygon mesh , materials science , covalent bond , visualization , implant , chemistry , composite material , computer science , surgery , medicine , biology , organic chemistry , artificial intelligence , computer graphics (images) , microbiology and biotechnology
The clinical advantage of MRI visualization of prostheses in soft tissue prolapses is very appealing as over 1 000 000 MRI‐transparent synthetic meshes are implanted annually, and postoperative complications such as mesh shrinkage and migration are frequent. Here, the synthesis of a new material composed of a DTPA‐Gd complex grafted onto a backbone of PMA via a covalent bond is described (DTPA‐Gd‐PMA). This new polymer is sprayed onto meshes and gives an MR signal for a long period without any significant release of Gd. In vitro cytocompatibility tests on fibroblasts show limited cytotoxicity. Microscopic investigations indicate that vital cells rapidly colonize the material. Finally, coated meshes implanted in rats are easily recognizable using an MR imaging system.