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Design of a Cellular‐Uptake‐Shielding Magnetic Catcher for Cancer Cell Separation
Author(s) -
Wang Ya,
Zhang Jing,
Jia HuiZhen,
Yang Juan,
Qin SiYong,
Liu ChenWei,
Zhuo RenXi,
Zhang XianZheng
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200205
Subject(s) - cancer cell , magnetic separation , chemistry , biophysics , glycine , electromagnetic shielding , nanotechnology , arginine , fluorescence , cancer , biochemistry , materials science , amino acid , biology , optics , physics , genetics , metallurgy , composite material
Abstract Fluorescent‐magnetic‐biotargeting multifunctional microcapsules (FMBMMs) are designed and fabricated via layer‐by‐layer assembly. It is found that the arginine‐glycine‐aspartate‐modified FMBMMs were capable of sensitively detecting and efficiently isolating approximately 80% target cancer cells within 20 min. More importantly, FMBMMs present a general template for identifying and separating multiple types of cancer cells simply by altering the recognition motif.