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Surfaces Resistant to Fouling from Biological Fluids: Towards Bioactive Surfaces for Real Applications
Author(s) -
RodriguezEmmenegger Cesar,
Houska Milan,
Alles Aldo Bologna,
Brynda Eduard
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200171
Subject(s) - methacrylamide , methacrylate , biofouling , fouling , saliva , chemistry , acrylamide , ethylene glycol , polymer , (hydroxyethyl)methacrylate , polymer chemistry , biochemistry , organic chemistry , membrane , polymerization , copolymer
The fouling from four human body fluids – blood plasma, cerebrospinal fluid, urine and saliva – and four animal fluids – foetal bovine and calf sera, egg and milk – relevant to human and veterinary medicine, immunology, biology and diagnostics is assessed on antifouling SAMs and on polymer brushes of oligo(ethylene glycol) methacrylate, 2‐hydroxyethyl methacrylate, carboxybetaine acrylamide and N ‐(2‐hydroxypropyl)methacrylamide synthesized via ATRP. While important deposits from the all biofluids are observed on SAMs, a superior resistance is achieved on polymer brushes. Importantly, only poly(CBAA) and poly(HPMA) are capable of resisting the fouling from the most challenging media, blood plasma and eggs.