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Human Elastin‐Based Recombinant Biopolymers Improve Mesenchymal Stem Cell Differentiation
Author(s) -
Çelebi Betül,
Cloutier Maxime,
Balloni Rodrigo,
Mantovani Diego,
Bandiera Antonella
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200170
Subject(s) - elastin , mesenchymal stem cell , regenerative medicine , tissue engineering , recombinant dna , chemistry , cell , cell culture , microbiology and biotechnology , biopolymer , scaffold , nanotechnology , c2c12 , materials science , biomedical engineering , biology , biochemistry , in vitro , polymer , engineering , myogenesis , genetics , organic chemistry , gene
Elastin‐based polypeptides are a class of smart biopolymers representing an important model in the design of biomaterials. The combination of biomimetic materials with cells that have great plasticity provides a promising strategy for the realization of highly engineered cell‐based constructs for regenerative medicine and tissue repair applications. Two recombinant biopolymers inspired by human elastin are assessed as coating agents to prepare biomimetic surfaces for cell culture. These substrates are assayed for hBM MSC culture. The coated surfaces are also characterized with AFM to evaluate the topographical features of the deposited biopolymers. The results suggest that the elastin‐derived biomimetic surfaces play a stimulatory role on osteogenic differentiation of MSCs.