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In vitro and in vivo Antitumor Activity of Doxorubicin‐Loaded Alginic‐Acid‐Based Nanoparticles
Author(s) -
Cheng Yuan,
Yu Shuling,
Wang Jingjing,
Qian Hanqing,
Wu Wei,
Jiang Xiqun
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200165
Subject(s) - in vivo , alginic acid , in vitro , chemistry , doxorubicin , biophysics , nanoparticle , preclinical imaging , methacrylate , materials science , nanotechnology , biochemistry , organic chemistry , polymer , biology , chemotherapy , copolymer , genetics , microbiology and biotechnology
The antitumor activities of DOX‐loaded alginic acid/poly[2‐(diethylamino)ethyl methacrylate] (ALG‐PDEA) nanoparticles are evaluated both in vitro and in vivo. TEM imaging shows that the ALG‐PDEA NPs have a spherical morphology with a size of about 120 nm. CLSM observations reveal that the negatively charged ALG‐PDEA NPs can be taken up well by cells. In vivo NIR fluorescence imaging shows that the ALG‐PDEA NPs can passively target the tumor area because of the EPR effect in the H22 tumor‐bearing mouse. In vivo antitumor efficacy examinations indicate that DOX‐loaded ALG‐PDEA NPs have significantly superior efficacy in impeding tumor growth compared to free DOX and low toxicity to living mice.