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Halloysite Clay Nanotubes for Resveratrol Delivery to Cancer Cells
Author(s) -
Vergaro Viviana,
Lvov Yuri M.,
Leporatti Stefano
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200121
Subject(s) - halloysite , aluminosilicate , resveratrol , polyelectrolyte , chemistry , drug delivery , nanotube , surface modification , chemical engineering , materials science , nanotechnology , polymer chemistry , organic chemistry , carbon nanotube , composite material , biochemistry , catalysis , polymer , engineering
Abstract Halloysite is natural aluminosilicate clay with hollow tubular structure which allows loading with low soluble drugs using their saturated solutions in organic solvents. Resveratrol, a polyphenol known for having antioxidant and antineoplastic properties, is loaded inside these clay nanotubes lumens. Release time of 48 h is demonstrated. Spectroscopic and ζ‐potential measurements are used to study the drug loading/release and for monitoring the nanotube layer‐by‐layer (LbL) coating with polyelectrolytes for further release control. Resveratrol‐loaded clay nanotubes are added to breast cell cultures for toxicity tests. Halloysite functionalization with LbL polyelectrolyte multilayers remarkably decrease nanotube self‐toxicity. MTT measurements performed with a neoplastic cell lines model system (MCF‐7) as function of the resveratrol‐loaded nanotubes concentration and incubation time indicate that drug‐loaded halloysite strongly increase of cytotoxicity leading to cell apoptosis.