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Cellular Interactions of a Water‐Soluble Supramolecular Polymer Complex of Carbon Nanotubes with Human Epithelial Colorectal Adenocarcinoma Cells
Author(s) -
Lee Yeonju,
Geckeler Kurt E.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200085
Subject(s) - caco 2 , carbon nanotube , colorectal cancer , chemistry , cancer cell , supramolecular chemistry , nanotechnology , viability assay , biophysics , cell , materials science , cancer , biochemistry , biology , organic chemistry , molecule , genetics
Water‐soluble, PAX‐loaded carbon nanotubes are fabricated by employing a synthetic polyampholyte, PDM. To investigate the suitability of the polyampholyte and the nanotubes as drug carriers, different cellular interactions such as the human epithelial Caco‐2 cells viability, their effect on the cell growth, and the change in the transepithelial electrical resistance in Caco‐2 cells are studied. The resulting complex is found to exhibit an effective anti‐cancer effect against colon cancer cells and an increased the reduction of the electrical resistance in the Caco‐2 cells when compared to the precursor PAX.