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Protein Conformational Studies for Macromolecularly Imprinted Polymers
Author(s) -
Kryscio David R.,
Fleming Michael Q.,
Peppas Nicholas A.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200068
Subject(s) - imprinting (psychology) , chemistry , molecular imprinting , polymer , conformational change , biophysics , nanotechnology , biochemistry , organic chemistry , materials science , biology , catalysis , selectivity , gene
CD is used to clearly show the negative impact of common ligands on the overall conformation of BSA, a typical protein template in macromolecularly imprinted polymers. This change occurs at concentrations far lower than those generally used in the literature. These findings are important as they offer insight into a potential fundamental reason for the lack of success in protein imprinting to date despite significant interest from the scientific community.