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Polymer Micelles for Delayed Release of Therapeutics from Drug‐Releasing Surfaces with Nanotubular Structures
Author(s) -
Aw Moom Sinn,
AddaiMensah Jonas,
Losic Dusan
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200012
Subject(s) - micelle , polymer , drug delivery , drug , chemical engineering , materials science , blank , chemistry , nanotechnology , organic chemistry , composite material , aqueous solution , pharmacology , medicine , engineering
Abstract A new approach to engineer a local drug delivery system with delayed release using nanostructured surface with nanotube arrays is presented. TNT arrays electrochemically generated on a titanium surface are used as a model substrate. Polymer micelles as drug carriers encapsulated with drug are loaded at the bottom of the TNT structure and their delayed release is obtained by loading blank micelles (without drug) on the top. The delayed and time‐controlled drug release is successfully demonstrated by controlling the ratio of blank and drug loaded‐micelles. The concept is verified using four different polymer micelles (regular and inverted) loaded with water‐insoluble (indomethacin) and water‐soluble drugs (gentamicin).