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Development of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineering
Author(s) -
Sun Chenghui,
Jin Xiaobing,
Holzwarth Jeremy M.,
Liu Xiaohua,
Hu Jiang,
Gupte Melanie J.,
Zhao Yaoming,
Ma Peter X.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200004
Subject(s) - scaffold , tissue engineering , extracellular matrix , tendon , regeneration (biology) , materials science , biomedical engineering , matrix (chemical analysis) , neural tissue engineering , chemistry , anatomy , composite material , microbiology and biotechnology , biochemistry , biology , medicine
A tissue‐engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro‐scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create single‐ and multiple‐channeled nanofibrous poly( L ‐lactic acid) scaffolds. The overall shape, the number and spatial arrangement of channels, the channel wall matrix architecture, the porosity and mechanical properties of the scaffolds are all tunable. The porous NF channel wall matrix provides an excellent microenvironment for protein adsorption and the attachment of PC12 neuronal cells and tendon fibroblast cells, showing potential for neural and tendon tissue regeneration.