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In vivo NIRF Imaging of Tumor Targetability of Nanosized Liposomes in Tumor‐Bearing Mice
Author(s) -
Lee Sangmin,
Lee SeungYoung,
Park Sangjin,
Ryu Ju Hee,
Na Jin Hee,
Koo Heebeom,
Lee Kyung Eun,
Jeon Hyesung,
Kwon Ick Chan,
Kim Kwangmeyung,
Jeong Seo Young
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201200001
Subject(s) - liposome , in vivo , chemistry , drug delivery , cationic liposome , drug carrier , cationic polymerization , biophysics , fluorescence lifetime imaging microscopy , fluorescence , biochemistry , transfection , organic chemistry , biology , physics , microbiology and biotechnology , quantum mechanics , gene
To optimize tumor targetability of nanosized liposomes for application as drug carriers, various liposomes are prepared by incorporating different amounts (10, 30, and 50 wt%) of cationic, anionic, and PEGylated lipids into neutral lipid. In vivo near‐infrared fluorescence images reveal that PEG‐PE/PC liposomes display high tumor accumulation in tumor‐bearing mice, while large amounts of DOTAP/PC liposomes are rapidly captured in the liver, resulting in poor tumor accumulation. These results demonstrate that optimization of the surface properties of liposomes is very important for their tumor targetability, and that in vivo imaging techniques are useful in developing and optimizing nanosized liposome‐based drug carriers.