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Novel Peptide‐Shelled Dendrimer with Dramatically Changeable Thermo‐Responsive Character
Author(s) -
Koga Tomoyuki,
Iimura Masayuki,
Higashi Nobuyuki
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100509
Subject(s) - dendrimer , lower critical solution temperature , chemistry , amidoamine , peptide , folding (dsp implementation) , poly(amidoamine) , nanotechnology , oligopeptide , biophysics , chemical engineering , polymer chemistry , materials science , copolymer , polymer , organic chemistry , biochemistry , electrical engineering , biology , engineering
The preparation of a novel peptide/dendrimer hybrid is reported in which an elastin‐like oligopeptide is successfully assembled onto a poly(amidoamine) dendrimer surface (G4‐ELP), and its unique thermo‐responsive behavior is discussed. As a result, the G4‐ELP is found to exhibit LCST behavior in the pH range 3–10 including physiological temperature range under neutral‐pH conditions. Moreover, cooperative interplay between the folding state of the ELP shell and the ionization state of the dendrimer core enables the G4‐ELP to control its LCST widely by pH variation. This achievement provides a new insight for the design of dual‐responsive materials with a potential in biological applications.