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Physically Crosslinked Nanocomposites from Silicate‐Crosslinked PEO: Mechanical Properties and Osteogenic Differentiation of Human Mesenchymal Stem Cells
Author(s) -
Gaharwar Akhilesh K.,
Kishore Vipuil,
Rivera Christian,
Bullock Whitney,
Wu ChiaJung,
Akkus Ozan,
Schmidt Gudrun
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100508
Subject(s) - nanocomposite , mesenchymal stem cell , silicate , regenerative medicine , materials science , chemical engineering , tissue engineering , chemistry , drug delivery , nanotechnology , biophysics , cell , biomedical engineering , microbiology and biotechnology , biochemistry , organic chemistry , biology , medicine , engineering
The mechanical and biological properties of silicate‐crosslinked PEO nanocomposites are studied. A strong correlation is observed between silicate concentration and mechanical properties. In vitro cell culture studies reveal that an increase in silicate concentration enhances the attachment and proliferation of human mesenchymal stem cells significantly. An upregulation in the expression of osteocalcin on nanocomposites compared to the tissue culture polystyrene control is observed. Together, these results suggest that silicate‐based nanocomposites are bioactive and have the potential to be used in a range of biotechnological and biomedical applications such as injectable matrices, biomedical coatings, drug delivery, and regenerative medicine.