Premium
Photo‐Crosslinked Biodegradable Hydrogels Prepared From Fumaric Acid Monoethyl Ester‐Functionalized Oligomers for Protein Delivery
Author(s) -
Jansen Janine,
Mihov George,
Feijen Jan,
Grijpma Dirk W.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100468
Subject(s) - self healing hydrogels , polymer chemistry , chemistry , monomer , ethylene glycol , fumaric acid , polymerization , copolymer , lysozyme , bovine serum albumin , polymer , organic chemistry , biochemistry
Photo‐crosslinkable, fumaric acid monoethyl ester‐functionalized triblock oligomers are synthesized and copolymerized with N ‐vinyl‐2‐pyrrolidone to form biodegradable photo‐crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D , L ‐lactide, trimethylene carbonate or a mixture of these monomers. Two model proteins, lysozyme and albumin, are incorporated in the hydrogels and their release is studied. The composition of the hydrophobic segments could be used to tune degradation behavior and release rates. Careful optimization of photo‐polymerization conditions is needed to limit conjugation of proteins to the hydrogels and protein denaturation.