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Injectable in situ Physically and Chemically Crosslinkable Gellan Hydrogel
Author(s) -
Du Hongwei,
Hamilton Paul,
Reilly Matthew,
Ravi Nathan
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100422
Subject(s) - gellan gum , self healing hydrogels , in situ , rheology , materials science , chemical engineering , tissue engineering , copolymer , nanotechnology , chemistry , polymer chemistry , polymer , organic chemistry , biomedical engineering , composite material , food science , engineering , medicine
An injectable, in situ physically and chemically crosslinkable gellan hydrogel is synthesized via gellan thiolation. The thiolation does not alter the gellan's unique 3‐D conformation, but leads to a lower phase transition temperature under physiological conditions and stable chemical crosslinking. The synthesis and hydrogels are characterized by 1 H NMR, FT‐IR, CD, or rheology measurements. The injectability and the tissue culture cell viability is also tested. The thiolated gellan hydrogel exhibits merits, such as ease for injection, quick gelation, lower gelling temperature, stable structure, and nontoxicity, which make it promising in biomedicine and bioengineering as an injectable hydrogel.