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Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure
Author(s) -
Levato Riccardo,
MateosTimoneda Miguel A.,
Planell Josep A.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100383
Subject(s) - dispersity , microporous material , biocompatible material , solvent , nanotechnology , drug delivery , chemistry , chemical engineering , materials science , fabrication , microparticle , polymer chemistry , organic chemistry , biomedical engineering , medicine , alternative medicine , engineering , pathology
PLA MPs are prepared via a novel and toxic‐chemical‐free fabrication route using ethyl lactate, a green solvent and FDA‐approved aroma. MPs are obtained by a solution jet break‐up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus‐like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent‐based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.