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Amphiphilic Cholic‐Acid‐Modified Dextran Sulfate and its Application for the Controlled Delivery of Superoxide Dismutase
Author(s) -
Xiong Yubing,
Qi Jianing,
Yao Ping
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100367
Subject(s) - amphiphile , chemistry , polyelectrolyte , cholic acid , superoxide dismutase , dextran , liposome , nanoparticle , drug delivery , biophysics , nuclear chemistry , polymer chemistry , biochemistry , organic chemistry , nanotechnology , copolymer , bile acid , enzyme , materials science , polymer , biology
A novel amphiphilic and biodegradable polyelectrolyte DS‐CA is prepared by the esterification of DS with CA. DS‐CA can self‐assemble into stable nanoparticles in water. SOD can effectively associate with DS‐CA at pH = 5.0 by virtue of electrostatic and hydrophobic interactions. SOD release from the complex nanoparticles is slow at pH = 1.2. The release at pH = 7.4 PBS shows an extended behavior and is tunable by changing the weight ratio of SOD to DS‐CA as well as the CA substitution degree. Increasing the CA substitution degree of DS‐CA can significantly enhance the cellular uptake of the loaded SOD. This study demonstrates that the amphiphilic DS‐CA provides a promising strategy for oral delivery of protein/peptide drugs.