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Two‐Component In situ Forming Supramolecular Hydrogels as Advanced Biomaterials in Vitreous Body Surgery
Author(s) -
Böhm Indra,
Strotmann Falko,
Koopmans Carsten,
Wolf Isabel,
Galla HansJoachim,
Ritter Helmut
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100357
Subject(s) - self healing hydrogels , biomaterial , biocompatible material , chemistry , in situ , polymer chemistry , biomedical engineering , materials science , chemical engineering , nanotechnology , organic chemistry , medicine , engineering
Abstract Polymeric β‐CD and poly{(2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid sodium salt) ‐co‐ [6‐(acrylamido)‐ N ‐adamantylhexaneamide]} are synthesized to build in situ forming hydrogels based on host/guest interactions, so called physical hydrogels. The use of these hydrogels as a potential vitreous body substitute is discussed and recommended. Potential changes in cell morphology and cell vitality of the retinal ganglion cell line RGC‐5 are determined. DSC experiments with artificial membrane structures are performed. The analyses show that β‐CD overrides the harmful effects of the highly toxic adamantyl‐modified polymer. Although the final hydrogel is considered to be biocompatible, the application as a biomaterial has to be reconsidered.