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DNA‐Inspired Hierarchical Polymer Design: Electrostatics and Hydrogen Bonding in Concert
Author(s) -
Hemp Sean T.,
Long Timothy E.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100355
Subject(s) - macromolecule , supramolecular chemistry , electrostatics , non covalent interactions , hydrogen bond , polymer , supramolecular polymers , nanotechnology , monomer , nucleobase , rational design , static electricity , chemistry , materials science , dna , polymer science , molecule , organic chemistry , physics , biochemistry , quantum mechanics
Nucleic acids and proteins, two of nature's biopolymers, assemble into complex structures to achieve desired biological functions and inspire the design of synthetic macromolecules containing a wide variety of noncovalent interactions including electrostatics and hydrogen bonding. Researchers have incorporated DNA nucleobases into a wide variety of synthetic monomers/polymers achieving stimuli‐responsive materials, supramolecular assemblies, and well‐controlled macromolecules. Recently, scientists utilized both electrostatics and complementary hydrogen bonding to orthogonally functionalize a polymer backbone through supramolecular assembly. Diverse macromolecules with noncovalent interactions will create materials with properties necessary for biomedical applications.