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Controlled Cell Proliferation on an Electrochemically Engineered Collagen Scaffold
Author(s) -
Gendron Robert,
Kumar M. Ramesh,
Paradis Helene,
Martin Darryl,
Ho Nhu,
Gardiner Danielle,
Merschrod S. Erika F.,
Poduska Kristin M.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100341
Subject(s) - stromal cell , scaffold , cornea , matrix (chemical analysis) , tissue engineering , extracellular matrix , biomedical engineering , chemistry , cell growth , microbiology and biotechnology , cell , biophysics , nanotechnology , materials science , pathology , biology , ophthalmology , biochemistry , medicine , chromatography
Therapies for corneal disease and injury often rely on artificial implants, but integrating cells into synthetic corneal materials remains a significant challenge. The electrochemically formed collagen‐based matrix presented here is non‐toxic to cells and controls the proliferation in the corneal fibroblasts seeded onto it. Histology and biomolecular studies show a behavior similar to corneal stromal cells in a native corneal environment. Not only is this result an important first step toward developing a more realistic, multi‐component artificial cornea, but it also opens possibilities for using this matrix to control and contain the growth of cells in engineered tissues.