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The Influence of Silkworm Species on Cellular Interactions with Novel PVA/Silk Sericin Hydrogels
Author(s) -
Lim Khoon S.,
Kundu Joydip,
Reeves April,
PooleWarren Laura A.,
Kundu Subhas C.,
Martens Penny J.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100292
Subject(s) - sericin , self healing hydrogels , silk , bombyx mori , methacrylate , adhesion , chemistry , polymer chemistry , cell adhesion , covalent bond , copolymer , chemical engineering , polymer science , materials science , biochemistry , polymer , composite material , organic chemistry , gene , engineering
Sericin peptides and PVA are chemically modified with methacrylate groups to produce a covalent PVA/sericin hydrogel. Preservation of the sericin bioactivity following methacrylation is confirmed, and PVA/sericin hydrogels are fabricated for both B. mori and A. mylitta sericin. Cell adhesion studies confirm the preservation of sericin bioactivity post incorporation in PVA gels. PVA/ A. mylitta gels are observed to facilitate cell adhesion to a significantly greater degree than PVA/ B. mori gels. Overall, the incorporation of sericin does not alter the physical properties of the PVA hydrogels but does result in significantly improved cellular interaction, particularly from A. mylitta gels.