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A Hydrophobic Starch Polymer for Nanoparticle‐Mediated Delivery of Docetaxel
Author(s) -
Dandekar Prajakta,
Jain Ratnesh,
Stauner Thomas,
Loretz Brigitta,
Koch Marcus,
Wenz Gerhard,
Lehr ClausMichael
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100244
Subject(s) - docetaxel , nanoparticle , chemistry , starch , internalization , polymer , drug delivery , solvent , hydrophobic effect , combinatorial chemistry , chemical engineering , nanotechnology , organic chemistry , cancer , materials science , biochemistry , cell , medicine , engineering
A hydrophobic starch derivative is used for safe and enhanced delivery of anticancer agents. The synthesis and characterization of propyl starch with a controlled degree of substitution to modulate the release of the encapsulated hydrophobic drug is reported. The application of this polymer for formulating nanoparticles of docetaxel, an anti‐cancer agent effective against numerous types of cancers but possessing intrinsic formulation difficulties is described. The solvent emulsification/diffusion technique is used and the synthesis is optimized with respect to several formulation parameters. Uptake studies with these nanoparticles indicate their enhanced internalization by the cancerous cells and their peri‐nuclear localization.