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Photocrosslinked Co‐Networks from Glycidylmethacrylated Gelatin and Poly(ethylene glycol) Methacrylates
Author(s) -
Pierce Benjamin F.,
Tronci Giuseppe,
Rößle Martin,
Neffe Axel T.,
Jung Friedrich,
Lendlein Andreas
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100232
Subject(s) - gelatin , ethylene glycol , methacrylate , swelling , biopolymer , ethylene oxide , peg ratio , polymer chemistry , chemistry , biomaterial , chemical engineering , materials science , polymer , polymerization , organic chemistry , copolymer , finance , economics , engineering
Biopolymer‐based systems with adjustable macroscopic properties that can be varied in a wide range using only small changes in chemical composition are promising candidates for biomaterial‐induced autoregeneration. Glycidylmethacrylated gelatin is photopolymerized with the addition of PEG mono‐ or dimethacrylate to form co‐networks in pH = 7.4 PBS. The degree of swelling ( Q ) and water uptake ( H ) in PBS at 37 °C are tailorable for PEGDMA co‐networks ( Q ≈ 250–650 vol%), while the storage modulus of swollen networks at 37 °C can be adjusted by the PEG(D)MA content ( G′ = 0.7–145 kPa). Indirect cytotoxicity tests on ethylene oxide sterilized films show non‐toxic responses for the homonetwork and all but one PEGDMA‐containing co‐networks materials.