Premium
A Collagen Peptide‐Based Physical Hydrogel for Cell Encapsulation
Author(s) -
Rubert Pérez Charles M.,
Panitch Alyssa,
Chmielewski Jean
Publication year - 2011
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100230
Subject(s) - self healing hydrogels , ethylene glycol , tissue engineering , cell encapsulation , triple helix , viscoelasticity , peptide , polymer , polymer chemistry , chemistry , lower critical solution temperature , chemical engineering , covalent bond , materials science , biophysics , biomedical engineering , composite material , copolymer , biochemistry , organic chemistry , stereochemistry , medicine , biology , engineering
Abstract Collagen peptide‐based hydrogels are prepared and characterized for application in 3D cell growth. Physical hydrogels are formed by covalently linking a collagen‐based peptide to an 8‐arm poly(ethylene glycol) star polymer. The resulting viscoelastic hydrogels have the ability to melt into a liquid‐like state near the melting temperature of the collagen triple helix and reform back into an elastic‐state at room temperature, adding a thermoresponsive feature to the material. In addition, the hydrogels possess desirable stiffness, as well as a highly cross‐linked network of pores where cells are found to reside, making the hydrogels promising scaffolds for the culture of hMSCs.