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Protein‐Resistant and Fibrinolytic Polyurethane Surfaces
Author(s) -
Wu Zhaoqiang,
Chen Hong,
Liu Xiaoli,
Brash John L.
Publication year - 2012
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.201100211
Subject(s) - plasmin , chemistry , protein adsorption , grafting , polymer chemistry , copolymer , polyurethane , adsorption , fibrinogen , peg ratio , lysine , polymer , chemical engineering , biochemistry , organic chemistry , amino acid , enzyme , finance , engineering , economics
Surfaces with resistance to non‐specific protein adsorption and a high capacity to bind plasminogen from plasma are developed for application as fibrinolytic surfaces in blood contact. A new method is reported for grafting poly(OEGMA ‐co‐ HEMA) copolymers on polyurethane surfaces. The OEGMA provides effective protein resistance due to the PEG side chains and the HEMA provides a high density of OH groups for attachment of lysine. Adsorption of fibrinogen from buffer and plasma to these surfaces is low, indicating significant protein resistance. Plasminogen binding from plasma is high, and clot dissolution on surfaces where plasminogen adsorbed from plasma is converted to plasmin is rapid.